Physics-Informed Machine Learning

This research area focuses on integrating physical knowledge into deep learning models for scientific and engineering problems. Modern neural networks are powerful function approximators, but in many physical systems we also have strong prior structure: governing equations, conservation laws, symmetries, and well-tested empirical relations. The core idea is to make these constraints part of learning, so that models do not merely fit observations but remain consistent with known science. This becomes especially valuable in regimes where measurements are expensive or sparse, where purely data-driven training can be brittle or inefficient.

A main mechanism for this integration is to incorporate physics directly into the training objective via differentiable constraints, an approach commonly known as Physics-Informed Neural Networks (PINNs). In this view, learning is guided not only by data mismatch but also by penalties that enforce governing relations, typically expressed through differential operators or other scientific laws. Building on this principle, we develop and study PINN-based methods across regimes of available physics and data: from PDE-solving settings with strong physical knowledge and limited observations, to inverse problems where key physical parameters must be identified from sparse measurements, and to applications where physics appears as structural priors rather than explicit PDEs. Recently, we have been exploring probabilistic extensions that combine physics-based constraints with latent-variable models to handle uncertainty when the available physical descriptions are incomplete or exhibit systematic discrepancies.

Team: Sai Karthikeya Vemuri, Tim Büchner

 

Research Directions

Our work spans two complementary directions: fundamental methodological advances that improve how physics constraints are represented and learned, and applications that use these tools to solve concrete scientific and engineering problems. The two directions inform each other, methodological improvements are typically motivated by bottlenecks encountered in applications, and new application domains regularly expose limitations that drive further methods work.
Fundamental Research

We develop new architectural and probabilistic building blocks that address core limitations of PINNs: scalability, expressivity, and uncertainty quantification.

  • Scalable and expressive representations: Functional tensor decomposition restructures the PINN architecture itself to improve scalability and expressivity, and extends to implicit neural representations more broadly. (ICPR 2024, WACV 2026, Pattern Recognition Letters 2026)
  • Uncertainty and calibration: Amortized, probabilistic extensions combine physics-based constraints with latent-variable models to calibrate predictions when the underlying physics is incompletely known. (UAI 2026)

 

Application-Driven Research

We apply these methods to domain problems where physical structure is available but data is sparse, noisy, or costly to obtain.

  • Inverse problems in physical sciences: Recovering underlying physical signals from indirect or corrupted measurements. (AISTATS 2026, IACM 2023)
  • Environmental and soil modeling: Estimating physical parameters governing subsurface and ecological processes from sparse field data. (ICCS 2024; ICLR-WS 2024)
  • Epidemiological dynamics: Modeling disease spread with physics-informed constraints on top of noisy, regionally sparse case data. (EurIPS-WS 2025)

 

Publications

 

2026
Aishwarya Venkataramanan, Sai Karthikeya Vemuri, Joachim Denzler:
APIC: Amortized Physics-Informed Calibration using Neural Processes.
Conference on Uncertainty in Artificial Intelligence (UAI). 2026. (accepted)
[bibtex] [doi] [code] [abstract]
Sai Karthikeya Vemuri, Adithya Ashok Chalain Valapil, Tim Büchner, Joachim Denzler:
RamPINN: Recovering Raman Spectra From Coherent Anti-Stokes Spectra Using Embedded Physics.
International Conference on Artificial Intelligence and Statistics (AISTATS). 2026.
[bibtex] [pdf] [doi] [abstract]
Sai Karthikeya Vemuri, Tim Büchner, Joachim Denzler:
F-INR: Functional Tensor Decomposition for Implicit Neural Representations.
Winter Conference on Applications of Computer Vision (WACV). 2026.
[bibtex] [web] [doi] [abstract]
Sai Karthikeya Vemuri, Tim Büchner, Julia Niebling, Joachim Denzler:
Scalable and Expressive Physics-Informed Neural Networks via Functional Tensor Decomposition.
Pattern Recognition Letters. 2026.
[bibtex] [pdf] [web] [doi] [code] [abstract]
2025
Phillip Rothenbeck, Sai Karthikeya Vemuri, Niklas Penzel, Joachim Denzler:
Modeling COVID-19 Dynamics in German States Using Physics-Informed Neural Networks.
EurIPS Workshop on Differentiable Systems and Scientific Machine Learning (EurIPS-WS). 2025.
[bibtex] [pdf] [doi] [abstract]
2024
Gideon Stein, Sai Karthikeya Vemuri, Yuanyuan Huang, Anne Ebeling, Nico Eisenhauer, Maha Shadaydeh, Joachim Denzler:
Investigating the Effects of Plant Diversity on Soil Thermal Diffusivity Using Physics- Informed Neural Networks.
ICLR Workshop on AI4DifferentialEquations In Science (ICLR-WS). 2024.
[bibtex] [pdf] [web] [abstract]
Sai Karthikeya Vemuri, Tim Büchner, Joachim Denzler:
Estimating Soil Hydraulic Parameters for Unsaturated Flow using Physics-Informed Neural Networks.
International Conference on Computational Science (ICCS). Pages 338-351. 2024.
[bibtex] [pdf] [doi] [abstract]
Sai Karthikeya Vemuri, Tim Büchner, Julia Niebling, Joachim Denzler:
Functional Tensor Decompositions for Physics-Informed Neural Networks.
International Conference on Pattern Recognition (ICPR). Pages 32-46. 2024. Best Paper Award
[bibtex] [pdf] [web] [doi] [code] [abstract]
2023
Sai Karthikeya Vemuri, Joachim Denzler:
Physics Informed Neural Networks for Aeroacoustic Source Estimation.
IACM Mechanistic Machine Learning and Digital Engineering for Computational Science Engineering and Technology. 2023.
[bibtex] [web] [doi] [abstract]